Biophotonics, Mesoscale microscopy, System biology
04/2022 – Present, PI at IDG/McGovern Institute for Brain Research, Tsinghua University
07/2021 – 01/2024, Assistant Professor at Department of Automation, Tsinghua University
07/2019 – 07/2021, Postdoc. at Department of Automation, Tsinghua University
09/2014 – 07/2019, Ph.D. Control Science and Engineering, Tsinghua University
10/2016–03/2018, Visiting Graduate Student, MGH, Harvard Medical School
09/2010 – 07/2014, B.Eng. Department of Automation, Tsinghua University
(# co-first author, *corresponding author)
1、Zhifeng Zhao#, Yiliang Zhou#, Bo Liu#, Jing He#, Jiayin Zhao, Yeyi Cai, Jingtao Fan, Xinyang Li, Zilin Wang, Zhi Lu, Jiamin Wu*, Hai Qi*, and Qionghai Dai*; Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue, Cell, 2023, 186 (11), 2475-2491.
2、Zhi Lu#, Yu Liu#, Manchang Jin, Xin Luo, Huanjing Yue, Zian Wang, Siqing Zuo, Yunmin Zeng, Jiaqi Fan, Yanwei Pang, Jiamin Wu*, Jingyu Yang*, and Qionghai Dai*. Virtual-scanning light-field microscopy for robust snapshot high-resolution volumetric imaging. Nature Methods, 2023, 20(5), 747-754.
3、Yitong Chen#, Maimaiti Nazhamaiti#, Han Xu#, Yao Meng, Tiankuang Zhou, Guangpu Li, Jingtao Fan, Qi Wei, Jiamin Wu*, Fei Qiao*, Lu Fang*, and Qionghai Dai*. All-analog photoelectronic chip for high-speed vision tasks. Nature, 2023, 623 (7985), 48-57.
4、Jiamin Wu#, Yuduo Guo#, Chao Deng#, Anke Zhang, Hui Qiao, Zhi Lu, Jiachen Xie, Lu Fang*, and Qionghai Dai*; An integrated imaging sensor for aberration-corrected 3D photography, Nature, 612: 62-71, 2022.
5、Jiamin Wu#; Zhi Lu#; Dong Jiang#; et al.; Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale. Cell, 2021, 184(12): 3318-3332.
Multiscale observation from subcellular structures to organs may lead to great breakthroughs in life science. However, it has long been restricted by the space-bandwidth product, optical aberrations, phototoxicity, and so on. I have been focusing on the great challenge of intravital mesoscale imaging and devoted myself to the interdisciplinary study of computational imaging and multiscale understanding of complicated biological phenomena. I have proposed a series of new microscopic imaging framework including camera-array-based gigapixel mesoscale microscopy, and scanning light field microscopy to overcome the barriers of intravital imaging, with orders of magnitude improvement in spatiotemporal resolution, imaging data throughput, and orders of magnitude reduction in phototoxicity for long-term observations. My study opens up a new horizon for the study of large-scale intercellular interactions in mammals. However, there remains great data challenges for analyzing and modeling the multiscale behaviors of the living systems spanning organelles, cells, tissue, and organs. Therefore, my future work focuses on the development of better intravital mesoscale imaging instruments and data analysis platforms, and try to build up a new data-driven paradigm for high-throughput biological discoveries with broad applications in neuroscience, oncology, and immunology, especially for the neural coding mechanism on the basis of millions of neurons.
2023 ICBS Frontiers of Science Award
2022 Ten most significant advances for optics in China, Optics Award
2022 Alibaba Damo Academy Young Fellow
2022 MIT Technology Review "Innovators under 35" (TR35) Asia Pacific
2022 SAIL Award, World Artificial Intelligence Conference
2021 IEEE Trans. on CSVT Best Associate Editor Award
2021 Top 10 creations of the postdoctoral innovative funding
2021 Ten most significant advances for optics in China, Nomination Optics Award
01/2021 – Present, Editorial Board Member, IEEE Transactions on CSVT
06/2023 – 01/2024,Guest Editor in Chief, Light: Science & Applications
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